Diclegis: What It Is, How It Works, and Alternatives You Should Know

When you're pregnant and fighting constant nausea, Diclegis, a prescription medication combining doxylamine and pyridoxine approved specifically for nausea and vomiting during pregnancy. Also known as doxylamine-pyridoxine, it's one of the few drugs cleared for use in early pregnancy when other remedies fail. Unlike random home remedies or over-the-counter pills, Diclegis was studied in clinical trials with pregnant women — and it works for many who haven’t found relief anywhere else.

It’s not a cure, but it’s a tool. The two active ingredients — doxylamine, an antihistamine that calms the part of the brain triggering nausea, and pyridoxine, a form of vitamin B6 that helps regulate neurotransmitters involved in nausea — team up to reduce vomiting and queasiness without crossing the placenta in harmful amounts. Many doctors start here because it’s been on the market for decades in other forms (like Unisom + B6), and Diclegis just packages them in a timed-release pill that’s easier to take.

But not everyone stays on it. Some women get drowsy. Others find it doesn’t touch their nausea. And some just want to try something cheaper or more natural. That’s where alternatives come in — like ginger supplements, acupuncture, or even plain vitamin B6 alone, which studies show can cut nausea by up to 70% in some cases. Then there’s Zofran, which works fast but isn’t officially approved for pregnancy and comes with more risk warnings. Diclegis sits in the middle: effective, studied, and safer than many alternatives — but not the only option.

What you’ll find in the articles below are real comparisons: how Diclegis stacks up against other pregnancy nausea treatments, what side effects people actually report, and why some doctors recommend trying B6 before jumping to prescription pills. You’ll also see how insurance covers it (or doesn’t), what generic versions exist, and how to talk to your provider if it’s not working. This isn’t a marketing page — it’s a practical guide built from real patient experiences and clinical data. If you’re struggling with morning sickness and feeling stuck, these posts will help you understand your options — not just what’s prescribed, but what actually works.